PPIRE12845

Target Protein Information
Protein_Name Vacuolar protein sorting-associated protein 4B
Protein_Sequence MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFGQEG
Organism_Source Homo sapiens
Functional_Classification ATPases
Cellular_Localization Cytoplasm
Gene_Names VPS4B
UniProt_ID O75351
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CHMP2B195-213
Peptide_Sequence KATISEEEDDDMKELENW
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2182.30
Aliphatic_Index 48.88889
Aromaticity 0.05556
Average_Rotatable_Bonds 4.27778
Charge_at_pH_7 -5.99239
Isoelectric_Point 3.66854
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 1007.80000
X_logP_energy -9.51630
Interaction Information
Affinity KD=273 mM
Affinity_Assay Bio-Layer Interferometry
PDB_ID 2JQK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title ESCRT-III recognition by VPS4 ATPases.
Release_Year 2007
PMID 17928862
DOI 10.1038/nature06172