PPIRE12887

Target Protein Information
Protein_Name Importin subunit alpha-1
Protein_Sequence MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
Organism_Source Mus musculus
Functional_Classification nuclear transport receptor
Cellular_Localization Cytoplasm
Gene_Names Kpna2
UniProt_ID P52293
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AR NLS K633A
Peptide_Sequence RKCYEAGMTLGARKLKAL
Peptide_Length 18
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2009.46
Aliphatic_Index 81.66667
Aromaticity 0.05556
Average_Rotatable_Bonds 3.94444
Charge_at_pH_7 3.93604
Isoelectric_Point 10.63357
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 837.64000
X_logP_energy -7.10896
Interaction Information
Affinity KD=72 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3BTR
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the nuclear import of the human androgen receptor.
Release_Year 2008
PMID 18319300
DOI 10.1242/jcs.022103