PPIRE12892

Target Protein Information
Protein_Name Neuronal acetylcholine receptor subunit alpha-7
Protein_Sequence MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Rattus norvegicus
Functional_Classification ligand-gated ion channels
Cellular_Localization Plasma membrane
Gene_Names Chrna7
UniProt_ID Q05941
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ApoE133-149
Peptide_Sequence RLRVRLASHLRKLRKRLL
Peptide_Length 18
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2284.88
Aliphatic_Index 151.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 4.61111
Charge_at_pH_7 8.08828
Isoelectric_Point 13.20310
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1030.37000
X_logP_energy -7.61188
Interaction Information
Affinity IC50=720 nM
Affinity_Assay whole-cell patch-clamp electrophysiology
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of nicotinic acetylcholine receptors by apolipoprotein E-derived peptides in rat hippocampal slices.
Release_Year 2004
PMID 15283956
DOI 10.1016/j.neuroscience.2004.05.045