PPIRE12903

Target Protein Information
Protein_Name THO complex subunit 4
Protein_Sequence MADKMDMSLDDIIKLNRSQRGGRGGGRGRGRAGSQGGRGGAVQAAARVNRGGGPMRNRPAIARGAAGGGRNRPAPYSRPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDTQRRPAQSINRGGMTRNRGSGGFGGGGTRRGTRGGSRGRGRGTGRNSKQQLSAEELDAQLDAYNARMDTS
Organism_Source Mus musculus
Functional_Classification nuclear export factors
Cellular_Localization Nucleus
Gene_Names Alyref
UniProt_ID O08583
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HVS_ORF57_103-120
Peptide_Sequence SCKTSWADRVREAAAQRR
Peptide_Length 18
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2091.34
Aliphatic_Index 38.33333
Aromaticity 0.05556
Average_Rotatable_Bonds 3.88889
Charge_at_pH_7 2.93792
Isoelectric_Point 11.30680
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1025.81000
X_logP_energy -13.81822
Interaction Information
Affinity KD=0.045 mM
Affinity_Assay NMR chemical shift titration
PDB_ID 2KT5
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57.
Release_Year 2011
PMID 21253573
DOI 10.1371/journal.ppat.1001244