PPIRE12934

Target Protein Information
Protein_Name Zinc finger protein DPF3
Protein_Sequence MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA
Organism_Source Homo sapiens
Functional_Classification PHD finger
Cellular_Localization Nucleus
Gene_Names DPF3
UniProt_ID Q92784
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3(1-18)
Peptide_Sequence ARTKQTARKSTGGKAPRK
Peptide_Length 18
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1942.26
Aliphatic_Index 16.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 6.99679
Isoelectric_Point 12.82564
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 963.02000
X_logP_energy -14.82539
Interaction Information
Affinity KD=2.3 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2KWK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Release_Year 2010
PMID 20613843
DOI 10.1038/nature09139