PPIRE12945

Target Protein Information
Protein_Name Chemotaxis protein CheY
Protein_Sequence MADKELKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGFSFIISDWNMPNMDGLELLKTIRADSAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLGM
Organism_Source Salmonella enterica I
Functional_Classification two-component response regulator
Cellular_Localization Cytoplasm
Gene_Names cheY
UniProt_ID A0A8F6NJ74
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name WTnonacCheZC19
Peptide_Sequence AGVVASQDQVDDLLDSLGF
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)N)C(C)C)C(C)C)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1949.10
Aliphatic_Index 117.89474
Aromaticity 0.05263
Average_Rotatable_Bonds 3.36842
Charge_at_pH_7 -4.00023
Isoelectric_Point 3.22803
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 862.96000
X_logP_energy -9.80930
Interaction Information
Affinity KD=2.2 uM
Affinity_Assay intrinsic fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Interaction of CheY with the C-terminal peptide of CheZ.
Release_Year 2008
PMID 18083806
DOI 10.1128/JB.01414-07