PPIRE12971

Target Protein Information
Protein_Name Gamma-aminobutyric acid receptor-associated protein-like 2
Protein_Sequence MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF
Organism_Source Homo sapiens
Functional_Classification LC3/GABARAP family
Cellular_Localization Cytoplasm
Gene_Names GABARAPL2
UniProt_ID P60520
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Human UBA5 LIR/UFIM peptide
Peptide_Sequence EIIHEDNEWGIELVSEVSE
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2227.37
Aliphatic_Index 112.63158
Aromaticity 0.05263
Average_Rotatable_Bonds 3.94737
Charge_at_pH_7 -6.90001
Isoelectric_Point 3.52034
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 976.24000
X_logP_energy -7.53420
Interaction Information
Affinity KD=1.7 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5)Required for Binding to Ubiquitin-like Proteins and Ufmylation.
Release_Year 2016
PMID 26929408
DOI 10.1074/jbc.M116.715474