PPIRE12974

Target Protein Information
Protein_Name von Hippel-Lindau disease tumor suppressor
Protein_Sequence MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names VHL
UniProt_ID P40337
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HIF-2alpha(523-541)OH_WT
Peptide_Sequence ELDLETLAPYIPMDGEDFQ
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Biotinylated
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2196.41
Aliphatic_Index 87.36842
Aromaticity 0.10526
Average_Rotatable_Bonds 3.63158
Charge_at_pH_7 -5.99620
Isoelectric_Point 3.14100
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 876.89000
X_logP_energy -5.41830
Interaction Information
Affinity KD=196 nM
Affinity_Assay Bio-Layer Interferometry
PDB_ID 6BVB
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title HIF-2Alpha-pVHL complex reveals broad genotype-phenotype correlations in HIF-2Alpha-driven disease.
Release_Year 2018
PMID 30135421
DOI 10.1038/s41467-018-05554-1