PPIRE13019
Target Protein Information
| Protein_Name | Calmodulin-1 |
|---|---|
| Protein_Sequence | MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK |
| Organism_Source | Homo sapiens |
| Functional_Classification | EF-hand proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | CALM1 |
| UniProt_ID | P0DP23 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | N19 |
|---|---|
| Peptide_Sequence | MDVFMKGLSKAKEGVVAAA |
| Peptide_Length | 19 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1952.36 |
|---|---|
| Aliphatic_Index | 87.36842 |
| Aromaticity | 0.05263 |
| Average_Rotatable_Bonds | 3.57895 |
| Charge_at_pH_7 | 0.99932 |
| Isoelectric_Point | 9.44155 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 28 |
| Number_of_Hydrogen_Bond_Donors | 26 |
| Topological_Polar_Surface_Area | 760.01000 |
| X_logP_energy | -6.05110 |
Interaction Information
| Affinity | KD=540 uM |
|---|---|
| Affinity_Assay | NMR chemical shift titration |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | NMR structure of calmodulin complexed to an N-terminally acetylated Alpha-synuclein peptide. |
| Release_Year | 2013 |
| PMID | 23607618 |
| DOI | 10.1021/bi400199p |