PPIRE13022

Target Protein Information
Protein_Name Golgi reassembly-stacking protein 2
Protein_Sequence MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQMTGTPITPLKDGFTEVQLSSVSPPSLSPPGTTGVEQSLSGLSISSAPPAVSNVLSTGVPTVPLLPPQVNQSLASMPPMNPATTLPSLMPLSAGLPSLPNLPSLSNFNLPAPHIMPGVGLPELGSPGLPPLPSLPPRNLPGIAPLPMLSDFLPSFPLVPEGSSAASAGEPLSSLPAMGPPSDPVMTTAKADASSLTVDVTSPASKVPTTVEDRVSDCTPAVEKPVSDADASEPS
Organism_Source Mus musculus
Functional_Classification Golgi matrix proteins
Cellular_Localization Cytoplasm
Gene_Names Gorasp2
UniProt_ID Q99JX3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name JAM-C peptide
Peptide_Sequence NYIRTSEEGDFRHKSSFVI
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2285.50
Aliphatic_Index 56.31579
Aromaticity 0.15789
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 0.09174
Isoelectric_Point 7.54340
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1021.76000
X_logP_energy -11.00326
Interaction Information
Affinity KD=3.7 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5GMI
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.
Release_Year 2017
PMID 28617811
DOI 10.1371/journal.pgen.1006803