PPIRE13057

Target Protein Information
Protein_Name Golgi reassembly-stacking protein 2
Protein_Sequence MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQMTGTPITPLKDGFTEVQLSSVSPPSLSPPGTTGVEQSLSGLSISSAPPAVSNVLSTGVPTVPLLPPQVNQSLASMPPMNPATTLPSLMPLSAGLPSLPNLPSLSNFNLPAPHIMPGVGLPELGSPGLPPLPSLPPRNLPGIAPLPMLSDFLPSFPLVPEGSSAASAGEPLSSLPAMGPPSDPVMTTAKADASSLTVDVTSPASKVPTTVEDRVSDCTPAVEKPVSDADASEPS
Organism_Source Mus musculus
Functional_Classification Golgi matrix proteins
Cellular_Localization Cytoplasm
Gene_Names Gorasp2
UniProt_ID Q99JX3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name JAM-A peptide
Peptide_Sequence SQPSTRSEGEFKQTSSFLV
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2115.28
Aliphatic_Index 35.78947
Aromaticity 0.10526
Average_Rotatable_Bonds 3.68421
Charge_at_pH_7 0.00124
Isoelectric_Point 6.53211
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 968.64000
X_logP_energy -14.17423
Interaction Information
Affinity KD=27 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.
Release_Year 2017
PMID 28617811
DOI 10.1371/journal.pgen.1006803