PPIRE13069

Target Protein Information
Protein_Name Importin subunit alpha-1
Protein_Sequence MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
Organism_Source Mus musculus
Functional_Classification importins
Cellular_Localization Cytoplasm
Gene_Names Kpna2
UniProt_ID P52293
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name XPG2
Peptide_Sequence VFGKKRRKLRRARGRKRKT
Peptide_Length 19
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2397.95
Aliphatic_Index 41.05263
Aromaticity 0.05263
Average_Rotatable_Bonds 4.78947
Charge_at_pH_7 11.99649
Isoelectric_Point 13.28646
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 47
Topological_Polar_Surface_Area 1170.75000
X_logP_energy -12.77911
Interaction Information
Affinity KD=3.8 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5EKG
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG)Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence.
Release_Year 2016
PMID 26812207
DOI 10.1016/j.jmb.2016.01.019