PPIRE13089

Target Protein Information
Protein_Name None
Protein_Sequence MQADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Bos taurus
Functional_Classification calcium-binding messenger proteins
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID A0AAF6ZWW2
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name VIP(10-28)
Peptide_Sequence YTRLRKQMAVKKYLNSILN
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2339.83
Aliphatic_Index 102.63158
Aromaticity 0.10526
Average_Rotatable_Bonds 4.31579
Charge_at_pH_7 4.99539
Isoelectric_Point 11.15360
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 999.17000
X_logP_energy -8.06236
Interaction Information
Affinity IC50=0.8 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of calmodulin-stimulated phosphodiesterase activity by vasoactive intestinal peptide.
Release_Year 1985
PMID 2989433
DOI 10.1111/j.1471-4159.1985.tb04036.x