PPIRE13096

Target Protein Information
Protein_Name Vascular endothelial growth factor A, long form
Protein_Sequence MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Organism_Source Homo sapiens
Functional_Classification growth factors
Cellular_Localization Extracellular
Gene_Names VEGFA
UniProt_ID P15692
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name L19K
Peptide_Sequence GGNECDAIRMWEWECFERK
Peptide_Length 19
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C5<->C15; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Biotin-Peg4
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2359.63
Aliphatic_Index 25.78947
Aromaticity 0.15789
Average_Rotatable_Bonds 4.10526
Charge_at_pH_7 -2.11872
Isoelectric_Point 4.29945
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 998.11000
X_logP_energy -7.77826
Interaction Information
Affinity KD=1 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 1KAT
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Enhancing peptide ligand binding to vascular endothelial growth factor by covalent bond formation.
Release_Year 2012
PMID 22537066
DOI 10.1021/bc300114d