PPIRE13105

Target Protein Information
Protein_Name General transcription factor IIH subunit 1
Protein_Sequence MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQSRRLMKKT
Organism_Source Homo sapiens
Functional_Classification general transcription factors
Cellular_Localization Nucleus
Gene_Names GTF2H1
UniProt_ID P32780
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DP1 acidic string N406V
Peptide_Sequence DEEDDDDEDEFDVEEDDDS
Peptide_Length 19
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2276.98
Aliphatic_Index 15.26316
Aromaticity 0.05263
Average_Rotatable_Bonds 4.15789
Charge_at_pH_7 -15.98690
Isoelectric_Point 2.73111
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1204.15000
X_logP_energy -15.04850
Interaction Information
Affinity KD=5.2 uM
Affinity_Assay NMR titration
PDB_ID 5GOW
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH.
Release_Year 2016
PMID 27825926
DOI 10.1016/j.jmb.2016.11.001