PPIRE13125

Target Protein Information
Protein_Name Histone H3.1
Protein_Sequence MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Organism_Source Homo sapiens
Functional_Classification histones
Cellular_Localization Nucleus
Gene_Names H3C1
UniProt_ID P68431
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3K9me3 peptide
Peptide_Sequence ARTKQTARKSTGGKAPGYCD
Peptide_Length 20
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2096.35
Aliphatic_Index 15.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 3.93471
Isoelectric_Point 10.63357
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 990.83000
X_logP_energy -15.26386
Interaction Information
Affinity KD=2 uM
Affinity_Assay peptide immunoprecipitation assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Broad ranges of affinity and specificity of anti-histone antibodies revealed by a quantitative peptide immunoprecipitation assay.
Release_Year 2012
PMID 23041298
DOI 10.1016/j.jmb.2012.09.022