PPIRE13227

Target Protein Information
Protein_Name Elongin-B/Elongin-C
Protein_Sequence MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ/MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
Organism_Source Homo sapiens
Functional_Classification ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names ELOB/ELOC
UniProt_ID Q15370/Q15369
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HIV-1 Vif SOCS-box peptide
Peptide_Sequence GHNKVGSLQYLALAALIKPKQIKPPLPSVRKLTEDRWNK
Peptide_Length 39
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4409.25
Aliphatic_Index 102.56410
Aromaticity 0.05128
Average_Rotatable_Bonds 3.76923
Charge_at_pH_7 6.08849
Isoelectric_Point 11.10602
Number_of_Hydrogen_Bond_Acceptors 59
Number_of_Hydrogen_Bond_Donors 60
Topological_Polar_Surface_Area 1786.23000
X_logP_energy -14.22586
Interaction Information
Affinity KD=1.2 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2MA9
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.
Release_Year 2013
PMID 24225024
DOI 10.1098/rsob.130100