PPIRE13236

Target Protein Information
Protein_Name Histone-lysine N-methyltransferase SETD7
Protein_Sequence MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
Organism_Source Homo sapiens
Functional_Classification methyltransferases
Cellular_Localization Nucleus
Gene_Names SETD7
UniProt_ID Q8WTS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p53 20-mer peptide
Peptide_Sequence LKSKKGQSTSRHKKLMFKTY
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2396.88
Aliphatic_Index 39.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.40000
Charge_at_pH_7 7.08627
Isoelectric_Point 11.47606
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1027.39000
X_logP_energy -10.71573
Interaction Information
Affinity KD=0.2 uM
Affinity_Assay fluorometric competition assay
PDB_ID 1XQH
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Regulation of p53 activity through lysine methylation.
Release_Year 2004
PMID 15525938
DOI 10.1038/nature03117