PPIRE13237
Target Protein Information
| Protein_Name | Tax1-binding protein 3 |
|---|---|
| Protein_Sequence | MSYTPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS |
| Organism_Source | Mus musculus |
| Functional_Classification | PDZ domain-containing proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | Tax1bp3 |
| UniProt_ID | Q9DBG9 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | C-terminal beta-catenin peptide(TIP-1 P45S) |
|---|---|
| Peptide_Sequence | NQLAWFDTDL |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1222.32 |
|---|---|
| Aliphatic_Index | 88.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.70000 |
| Charge_at_pH_7 | -2.00112 |
| Isoelectric_Point | 3.49188 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 522.02000 |
| X_logP_energy | -3.68860 |
Interaction Information
| Affinity | KD=2.85 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 3DIW |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis of beta-catenin recognition by Tax-interacting protein-1. |
| Release_Year | 2008 |
| PMID | 18835279 |
| DOI | 10.1016/j.jmb.2008.09.034 |