PPIRE13247

Target Protein Information
Protein_Name Beta sliding clamp
Protein_Sequence MIQFSINRTLFIHALNTTKRAISTKNAIPILSSIKIEVTSTGVTLTGSNGQISIENTIPVSNENAGLLITSPGAILLEASFFINIISSLPDISINVKEIEQHQVVLTSGKSEITLKGKDVDQYPRLQEVSTENPLILKTKLLKSIIAETAFAASLQESRPILTGVHIVLSNHKDFKAVATDSHRMSQRLITLDNTSADLMVVLPSKSLREFSAVFTDDIETVEVFFSPSQILFRSEHISFYTRLLEGNYPDTDRLLMTEFETEVVFNTQSLRHAMERAFLISNATQNGTVKLEITQNHISAHVNSPEVGKVNEDLDIVSQSGSDLTISFNPTYLIESLKAIKSETVKIHFLSPVRPFTLTPGDEEESFIQLITPVRTN
Organism_Source Streptococcus pyogenes
Functional_Classification processivity factor
Cellular_Localization Cytoplasm
Gene_Names dnaN
UniProt_ID Q9EVR1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name S. pyogenes PolC C-terminal 20-mer
Peptide_Sequence MGILGNMPEDNQLSLFDDFF
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Tamn
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2303.59
Aliphatic_Index 78.00000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 -3.99890
Isoelectric_Point 3.26047
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 906.13000
X_logP_energy -6.90530
Interaction Information
Affinity KD=1.5 uM
Affinity_Assay fluorescence anisotropy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.
Release_Year 2008
PMID 18678908
DOI 10.1073/pnas.0804754105