PPIRE13263

Target Protein Information
Protein_Name Streptavidin
Protein_Sequence MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ
Organism_Source Streptomyces avidinii
Functional_Classification biotin-binding proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P22629
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p25
Peptide_Sequence CWHPQAGC
Peptide_Length 8
Peptide_SMILES C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CS)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C1<->C8; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 901.03
Aliphatic_Index 12.50000
Aromaticity 0.12500
Average_Rotatable_Bonds 2.87500
Charge_at_pH_7 -0.03506
Isoelectric_Point 7.25316
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 345.79000
X_logP_energy -3.23570
Interaction Information
Affinity KD=12.6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title An in-the-groove view of DNA structures in complexes with proteins.
Release_Year 1996
PMID 8636970
DOI 10.1006/jmbi.1996.0055