PPIRE13269

Target Protein Information
Protein_Name 14-3-3 protein gamma
Protein_Sequence MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
Organism_Source Homo sapiens
Functional_Classification scaffold proteins
Cellular_Localization Cytoplasm
Gene_Names YWHAG
UniProt_ID P61981
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name R18
Peptide_Sequence PHCVPKNLSWLNLEANMCLP
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2279.72
Aliphatic_Index 97.50000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.45000
Charge_at_pH_7 -0.03358
Isoelectric_Point 7.25383
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 841.94000
X_logP_energy -6.17830
Interaction Information
Affinity IC50=3.5 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Fluorescence polarization assay to quantify protein-protein interactions in an HTS format.
Release_Year 2015
PMID 25859974
DOI 10.1007/978-1-4939-2425-7_35