PPIRE13275

Target Protein Information
Protein_Name Hemagglutinin
Protein_Sequence MKTIIALSYIFCLALGQDLPGNDNNTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPDSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGQSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI
Organism_Source Influenza A virus (strain A/Northern Territory/60/1968 H3N2)
Functional_Classification hemagglutinin
Cellular_Localization Extracellular
Gene_Names HA
UniProt_ID P03436
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EB
Peptide_Sequence RRKKAAVALLPAVLLALLAP
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2084.67
Aliphatic_Index 176.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.35000
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 774.48000
X_logP_energy -2.88556
Interaction Information
Affinity EC50=3.2 uM
Affinity_Assay hemagglutination inhibition assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Identification of the minimal active sequence of an anti-influenza virus peptide.
Release_Year 2011
PMID 21220525
DOI 10.1128/AAC.01428-10