PPIRE13302

Target Protein Information
Protein_Name Synaptosomal-associated protein 25
Protein_Sequence MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Organism_Source Bos taurus
Functional_Classification SNARE
Cellular_Localization Plasma membrane
Gene_Names SNAP25
UniProt_ID Q17QQ3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SNAP-25(187-206)
Peptide_Sequence SNKTRIDEANQRATKMLGSG
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2177.42
Aliphatic_Index 49.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.90000
Charge_at_pH_7 1.99961
Isoelectric_Point 10.77375
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1076.85000
X_logP_energy -16.35606
Interaction Information
Affinity IC50=20 uM
Affinity_Assay catecholamine release assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).
Release_Year 1995
PMID None
DOI 10.1016/0014-5793(95)00944-2