PPIRE13303
Target Protein Information
| Protein_Name | Periplasmic pH-dependent serine endoprotease DegQ |
|---|---|
| Protein_Sequence | MKKQTQLLSALALSVGLTLSASFQAVASIPGQVADQAPLPSLAPMLEKVLPAVVSVRVEGTASQGQKIPEEFKKFFGDDLPDQPAQPFEGLGSGVIINASKGYVLTNNHVINQAQKISIQLNDGREFDAKLIGSDDQSDIALLQIQNPSKLTQIAIADSDKLRVGDFAVAVGNPFGLGQTATSGIVSALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSVGIGFAIPSNMARTLAQQLIDFGEIKRGLLGIKGTEMSADIAKAFNLDVQRGAFVSEVLPGSGSAKAGVKAGDIITSLNGKPLNSFAELRSRIATTEPGTKVKLGLLRNGKPLEVEVTLDTSTSSSASAEMITPALEGATLSDGQLKDGGKGIKIDEVVKGSPAAQAGLQKDDVIIGVNRDRVNSIAEMRKVLAAKPAIIALQIVRGNESIYLLMR |
| Organism_Source | Escherichia coli (strain K12) |
| Functional_Classification | serine proteases |
| Cellular_Localization | Extracellular |
| Gene_Names | degQ |
| UniProt_ID | P39099 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | DegQ activating peptide |
|---|---|
| Peptide_Sequence | SPMFKGVLDMMYGGMRGYQV |
| Peptide_Length | 20 |
| Peptide_SMILES | CSCC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2267.72 |
|---|---|
| Aliphatic_Index | 48.50000 |
| Aromaticity | 0.15000 |
| Average_Rotatable_Bonds | 3.70000 |
| Charge_at_pH_7 | 0.99643 |
| Isoelectric_Point | 9.14509 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 32 |
| Number_of_Hydrogen_Bond_Donors | 29 |
| Topological_Polar_Surface_Area | 836.43000 |
| X_logP_energy | -5.72413 |
Interaction Information
| Affinity | KD=16 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 3STJ |
| Type | Allosteric modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. |
| Release_Year | 2011 |
| PMID | 21685389 |
| DOI | 10.1074/jbc.M111.243832 |