PPIRE13323

Target Protein Information
Protein_Name Apical membrane antigen 1
Protein_Sequence CPVFGKGIIIENSKTTFLTPVATENQDLKDGGFAFPPTKPLMSPMTLDHMRDFYKDNEYVKNLDELTLCSRHAGNMNPDNDKNSNYKYPAVYDYNDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAKDISFQNYTYLSKNVVDNWEKVCPRKNLQNAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETHKCEIFNVKPTCLINNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDNMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDEPQHYGKSNSRNDEMLD
Organism_Source Plasmodium falciparum
Functional_Classification Type I transmembrane protein
Cellular_Localization Plasma membrane
Gene_Names AMA1
UniProt_ID A0A0X8IHV3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name R1
Peptide_Sequence VFAEFLPLFSKFGSRMHILK
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2367.88
Aliphatic_Index 97.50000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.85000
Charge_at_pH_7 2.09008
Isoelectric_Point 10.78905
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 827.81000
X_logP_energy -2.33223
Interaction Information
Affinity KD=145 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3SRJ
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural and functional insights into the malaria parasite moving junction complex.
Release_Year 2012
PMID 22737069
DOI 10.1371/journal.ppat.1002755