PPIRE13334

Target Protein Information
Protein_Name Interleukin-17A
Protein_Sequence MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
Organism_Source Homo sapiens
Functional_Classification interleukins
Cellular_Localization Extracellular
Gene_Names IL17A
UniProt_ID Q16552
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 45675
Peptide_Sequence AYECPRLEYDMFGALHCLPS
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C4<->C17; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2315.66
Aliphatic_Index 68.50000
Aromaticity 0.15000
Average_Rotatable_Bonds 3.45000
Charge_at_pH_7 -2.03276
Isoelectric_Point 4.42136
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 861.81000
X_logP_energy -5.39093
Interaction Information
Affinity IC50=61.7 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
Release_Year 2018
PMID 29329326
DOI 10.1371/journal.pone.0190850