PPIRE13335

Target Protein Information
Protein_Name Interleukin-17A
Protein_Sequence MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
Organism_Source Homo sapiens
Functional_Classification interleukins
Cellular_Localization Extracellular
Gene_Names IL17A
UniProt_ID Q16552
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 585-1
Peptide_Sequence DSSAVCWAFPHHPLCHMKAT
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C15; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2238.58
Aliphatic_Index 49.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.20000
Charge_at_pH_7 0.14691
Isoelectric_Point 7.51549
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 824.48000
X_logP_energy -7.17040
Interaction Information
Affinity KD=0.15 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
Release_Year 2018
PMID 29329326
DOI 10.1371/journal.pone.0190850