PPIRE13371
Target Protein Information
| Protein_Name | Importin subunit alpha-1 |
|---|---|
| Protein_Sequence | MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF |
| Organism_Source | Mus musculus |
| Functional_Classification | nuclear transport receptors |
| Cellular_Localization | Cytoplasm |
| Gene_Names | Kpna2 |
| UniProt_ID | P52293 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FEN1NLS |
|---|---|
| Peptide_Sequence | SSAKRKEPEPKGSTKKKAKT |
| Peptide_Length | 20 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2186.54 |
|---|---|
| Aliphatic_Index | 10.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | 5.99947 |
| Isoelectric_Point | 11.18478 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 36 |
| Number_of_Hydrogen_Bond_Donors | 36 |
| Topological_Polar_Surface_Area | 1018.43000 |
| X_logP_energy | -14.07253 |
Interaction Information
| Affinity | KD=42 nM |
|---|---|
| Affinity_Assay | solid-phase binding assay |
| PDB_ID | 3UVU |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis of nuclear import of flap endonuclease 1 (FEN1). |
| Release_Year | 2012 |
| PMID | 22751659 |
| DOI | 10.1107/S0907444912010281 |