PPIRE13377

Target Protein Information
Protein_Name Calsenilin isoform 4
Protein_Sequence MRQLPAGPSSLACSGCKAGRLVTVPFSSRDAEDQGSREGIGWQPPGRSWAHTTEQEGKHQVAKATVHPPGPDALLLNQVDPVQCCPTRL
Organism_Source Mus musculus
Functional_Classification calcium-binding proteins
Cellular_Localization Cytoplasm
Gene_Names Kcnip3
UniProt_ID P0C092
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Kv4.3(2-22)
Peptide_Sequence AAGVAAWLPFARAAAIGWMPV
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)N)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fitc
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2126.55
Aliphatic_Index 102.85714
Aromaticity 0.14286
Average_Rotatable_Bonds 2.76190
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 721.22000
X_logP_energy -2.36003
Interaction Information
Affinity KD=5 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Pb2+ Binds to Downstream Regulatory Element Antagonist Modulator (DREAM)and Modulates Its Interactions with Binding Partners: A Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.
Release_Year 2018
PMID 30399317
DOI 10.1021/acschemneuro.8b00335