PPIRE13401

Target Protein Information
Protein_Name Baculoviral IAP repeat-containing protein 5
Protein_Sequence MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
Organism_Source Homo sapiens
Functional_Classification inhibitor of apoptosis proteins
Cellular_Localization Nucleus
Gene_Names BIRC5
UniProt_ID O15392
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Histone H3 Thr3ph tail
Peptide_Sequence ARXKQTARKSTGGKAPRKQLA
Peptide_Length 21
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification X3=phosphothreonine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2210.57
Aliphatic_Index 37.61905
Aromaticity 0.00000
Average_Rotatable_Bonds 3.76190
Charge_at_pH_7 6.99679
Isoelectric_Point 12.82564
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1073.18000
X_logP_energy -15.78889
Interaction Information
Affinity KD=1 uM
Affinity_Assay fluorescence anisotropy
PDB_ID 4A0J
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the recognition of phosphorylated histone h3 by the survivin subunit of the chromosomal passenger complex.
Release_Year 2011
PMID 22032967
DOI 10.1016/j.str.2011.09.002