PPIRE13438

Target Protein Information
Protein_Name Osteoclast-associated immunoglobulin-like receptor
Protein_Sequence MALVLILQLLTLWPLCHTDITPSVPPASYHPKPWLGAQPATVVTPGVNVTLRCRAPQPAWRFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGIYRCCYRRPDWGPGVWSQPSDVLELLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFVLYREGVAAPLQYRHSAQPWADFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWEGEGPEARPASSAPGMQAPGPPPSDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGV
Organism_Source Homo sapiens
Functional_Classification immunoglobulin superfamily
Cellular_Localization Plasma membrane
Gene_Names OSCAR
UniProt_ID Q8IYS5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DB316
Peptide_Sequence GPXGPXGPXGPAGFXGPXGPX
Peptide_Length 21
Peptide_SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification X3=Hydroxyproline; X6=Hydroxyproline; X9=Hydroxyproline; X15=Hydroxyproline; X18=Hydroxyproline; X21=Hydroxyproline
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1560.65
Aliphatic_Index 4.76190
Aromaticity 0.04762
Average_Rotatable_Bonds 1.76190
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 592.58000
X_logP_energy -11.39770
Interaction Information
Affinity KD=1.5 mM
Affinity_Assay solid-phase binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for collagen recognition by the immune receptor OSCAR.
Release_Year 2016
PMID 26552697
DOI 10.1182/blood-2015-08-667055