PPIRE13459

Target Protein Information
Protein_Name Calsenilin isoform 4
Protein_Sequence MRQLPAGPSSLACSGCKAGRLVTVPFSSRDAEDQGSREGIGWQPPGRSWAHTTEQEGKHQVAKATVHPPGPDALLLNQVDPVQCCPTRL
Organism_Source Mus musculus
Functional_Classification calcium-binding proteins
Cellular_Localization Cytoplasm
Gene_Names Kcnip3
UniProt_ID P0C092
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Kv4.3(70-90)
Peptide_Sequence LLGSTEKEFFFNEDTKEYFFD
Peptide_Length 21
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fitc
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2606.82
Aliphatic_Index 37.14286
Aromaticity 0.28571
Average_Rotatable_Bonds 4.09524
Charge_at_pH_7 -3.99546
Isoelectric_Point 3.84412
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 1045.17000
X_logP_energy -6.72440
Interaction Information
Affinity KD=11 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Pb2+ Binds to Downstream Regulatory Element Antagonist Modulator (DREAM)and Modulates Its Interactions with Binding Partners: A Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.
Release_Year 2018
PMID 30399317
DOI 10.1021/acschemneuro.8b00335