PPIRE13495

Target Protein Information
Protein_Name Acetylcholine receptor subunit alpha
Protein_Sequence MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Organism_Source Tetronarce californica
Functional_Classification ligand-gated ion channels
Cellular_Localization Plasma membrane
Gene_Names CHRNA1
UniProt_ID P02710
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Catestatin
Peptide_Sequence SSMKLSFRARAYGFRGPGPQL
Peptide_Length 21
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2326.70
Aliphatic_Index 46.66667
Aromaticity 0.14286
Average_Rotatable_Bonds 3.52381
Charge_at_pH_7 3.99683
Isoelectric_Point 12.22714
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 963.47000
X_logP_energy -10.51909
Interaction Information
Affinity IC50=300 nM
Affinity_Assay equilibrium radioligand binding assay
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A(352-372))with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism.
Release_Year 2000
PMID 11062327
DOI 10.1016/S0167-0115(00)00135-X