PPIRE13518

Target Protein Information
Protein_Name Sonic hedgehog protein
Protein_Sequence MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
Organism_Source Homo sapiens
Functional_Classification morphogens
Cellular_Localization Extracellular
Gene_Names SHH
UniProt_ID Q15465
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HHIP L2 peptide
Peptide_Sequence GCGMITLDDMEEMDGLSDFCG
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<->C21; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2239.50
Aliphatic_Index 55.71429
Aromaticity 0.04762
Average_Rotatable_Bonds 3.61905
Charge_at_pH_7 -6.12063
Isoelectric_Point 3.11604
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 909.58000
X_logP_energy -9.87870
Interaction Information
Affinity IC50=150 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Release_Year 2009
PMID 19561609
DOI 10.1038/nsmb.1632