PPIRE13520

Target Protein Information
Protein_Name Ferrichrome outer membrane transporter/phage receptor
Protein_Sequence MARSKTAQPKHSLRKIAVVVATAVSGMSVYAQAAVEPKEDTITVTAAPAPQESAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNPVNTDFDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVATATFRF
Organism_Source Escherichia coli (strain K12)
Functional_Classification TonB-dependent receptors
Cellular_Localization Plasma membrane
Gene_Names fhuA
UniProt_ID P06971
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MccJ25
Peptide_Sequence GGAGHVPEYFVGIGTPISFYG
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)CN)C(C)C)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)O)[C@@H](C)CC)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Main chain-side chain cyclization; G1<->E8; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2125.37
Aliphatic_Index 69.52381
Aromaticity 0.19048
Average_Rotatable_Bonds 2.85714
Charge_at_pH_7 -0.91103
Isoelectric_Point 5.36338
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 774.64000
X_logP_energy -6.09510
Interaction Information
Affinity KD=1.2 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4CU4
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides.
Release_Year 2014
PMID 24705590
DOI 10.1038/nchembio.1499