PPIRE13546

Target Protein Information
Protein_Name Chromobox protein homolog 5
Protein_Sequence MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
Organism_Source Homo sapiens
Functional_Classification chromodomain proteins
Cellular_Localization Nucleus
Gene_Names CBX5
UniProt_ID P45973
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Histone H3(1-22)K9me3 peptide
Peptide_Sequence ARTKQTARXSTGGKAPRKQLAY
Peptide_Length 22
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification X9=trimethyl-lysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2346.68
Aliphatic_Index 35.90909
Aromaticity 0.04545
Average_Rotatable_Bonds 3.63636
Charge_at_pH_7 5.99624
Isoelectric_Point 12.26643
Number_of_Hydrogen_Bond_Acceptors 36
Number_of_Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1116.72000
X_logP_energy -16.10399
Interaction Information
Affinity KD=0.17 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Extended string-like binding of the phosphorylated HP1Alpha N-terminal tail to the lysine 9-methylated histone H3 tail.
Release_Year 2016
PMID 26934956
DOI 10.1038/srep22527