PPIRE13554

Target Protein Information
Protein_Name Macrophage scavenger receptor types I and II
Protein_Sequence MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS
Organism_Source Mus musculus
Functional_Classification scavenger receptors
Cellular_Localization Plasma membrane
Gene_Names Msr1
UniProt_ID P30204
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PEG30 kDa-Cys-Trp-Lys20
Peptide_Sequence CWKKKKKKKKKKKKKKKKKKKK
Peptide_Length 22
Peptide_SMILES NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CS)C(=O)O
Chemical_Modification C1=maleimide-PEG30kDa
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Pegylation
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2870.85
Aliphatic_Index 0.00000
Aromaticity 0.04545
Average_Rotatable_Bonds 5.72727
Charge_at_pH_7 19.93011
Isoelectric_Point 11.75455
Number_of_Hydrogen_Bond_Acceptors 44
Number_of_Hydrogen_Bond_Donors 45
Topological_Polar_Surface_Area 1210.61000
X_logP_energy -7.18710
Interaction Information
Affinity IC50=5.5 uM
Affinity_Assay in vivo gamma-counting biodistribution assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure-Activity Relationship of PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors for Non-Viral Gene Delivery.
Release_Year 2015
PMID 26485572
DOI 10.1021/acs.molpharmaceut.5b00513