PPIRE13589
Target Protein Information
| Protein_Name | Actin, alpha skeletal muscle |
|---|---|
| Protein_Sequence | MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF |
| Organism_Source | Oryctolagus cuniculus |
| Functional_Classification | cytoskeletal proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | ACTA1 |
| UniProt_ID | P68135 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Actin subdomain 4 fragment Arg177-Tyr198 |
|---|---|
| Peptide_Sequence | RLDLAGRDLTDYLMKILTERGY |
| Peptide_Length | 22 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2613.03 |
|---|---|
| Aliphatic_Index | 110.90909 |
| Aromaticity | 0.09091 |
| Average_Rotatable_Bonds | 4.04545 |
| Charge_at_pH_7 | -0.00091 |
| Isoelectric_Point | 6.58999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 36 |
| Number_of_Hydrogen_Bond_Donors | 41 |
| Topological_Polar_Surface_Area | 1116.26000 |
| X_logP_energy | -8.24259 |
Interaction Information
| Affinity | KD=200 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Actin-actin contact: inhibition of actin-polymerization by subdomain 4 peptide fragments. |
| Release_Year | 1992 |
| PMID | 1429530 |
| DOI | 10.1093/oxfordjournals.jbchem.a123912 |