PPIRE13602

Target Protein Information
Protein_Name Transcription factor MYC3
Protein_Sequence MNGTTSSINFLTSDDDASAAAMEAFIGTNHHSSLFPPPPQQPPQPQFNEDTLQQRLQALIESAGENWTYAIFWQISHDFDSSTGDNTVILGWGDGYYKGEEDKEKKKNNTNTAEQEHRKRVIRELNSLISGGIGVSDESNDEEVTDTEWFFLVSMTQSFVNGVGLPGESFLNSRVIWLSGSGALTGSGCERAGQGQIYGLKTMVCIATQNGVVELGSSEVISQSSDLMHKVNNLFNFNNGGGNNGVEASSWGFNLNPDQGENDPALWISEPTNTGIESPARVNNGNNSNSNSKSDSHQISKLEKNDISSVENQNRQSSCLVEKDLTFQGGLLKSNETLSFCGNESSKKRTSVSKGSNNDEGMLSFSTVVRSAANDSDHSDLEASVVKEAIVVEPPEKKPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYSLRAVVPNVSKMDKASLLGDAISYINELKSKLQQAESDKEEIQKKLDGMSKEGNNGKGCGSRAKERKSSNQDSTASSIEMEIDVKIIGWDVMIRVQCGKKDHPGARFMEALKELDLEVNHASLSVVNDLMIQQATVKMGSQFFNHDQLKVALMTKVGENY
Organism_Source Arabidopsis thaliana
Functional_Classification basic helix-loop-helix transcription factors
Cellular_Localization Nucleus
Gene_Names MYC3
UniProt_ID Q9FIP9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Jas22JAZ9
Peptide_Sequence SVLNPQARVVSQRLFGMDPNPN
Peptide_Length 22
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2439.77
Aliphatic_Index 79.54545
Aromaticity 0.04545
Average_Rotatable_Bonds 3.45455
Charge_at_pH_7 0.99842
Isoelectric_Point 10.39777
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 1065.06000
X_logP_energy -13.05196
Interaction Information
Affinity IC50=0.42 uM
Affinity_Assay ELISA
PDB_ID 4RS9
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Release_Year 2015
PMID 26258305
DOI 10.1038/nature14661