PPIRE13609

Target Protein Information
Protein_Name Nuclear receptor subfamily 0 group B member 2
Protein_Sequence MSSGQSGVCPCQGSAGRPTILYALLSPSPRTRPVAPASHSHCLCQQQRPVRLCAPHRTCREALDVLAKTVAFLRNLPSFCHLPHEDQRRLLECCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEASSGTQGAQPSDRPQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR
Organism_Source Mus musculus
Functional_Classification orphan nuclear receptors
Cellular_Localization Nucleus
Gene_Names Nr0b2
UniProt_ID Q62227
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EID1 peptide
Peptide_Sequence YSGAMHRVSAALEEANKVFLRT
Peptide_Length 22
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Biotin
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2450.80
Aliphatic_Index 80.00000
Aromaticity 0.09091
Average_Rotatable_Bonds 3.68182
Charge_at_pH_7 1.09129
Isoelectric_Point 9.29882
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1051.53000
X_logP_energy -10.76986
Interaction Information
Affinity IC50=5 uM
Affinity_Assay ELISA
PDB_ID 4NUF
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural insights into gene repression by the orphan nuclear receptor SHP.
Release_Year 2014
PMID 24379397
DOI 10.1073/pnas.1322827111