PPIRE13614

Target Protein Information
Protein_Name B-lymphocyte antigen CD20
Protein_Sequence MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Organism_Source Homo sapiens
Functional_Classification calcium channel
Cellular_Localization Plasma membrane
Gene_Names MS4A1
UniProt_ID P11836
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CD20-LUMABS-1
Peptide_Sequence YNCEPANPSEKNSPSTQYCYSI
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C3<->C19; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2495.67
Aliphatic_Index 22.27273
Aromaticity 0.13636
Average_Rotatable_Bonds 3.36364
Charge_at_pH_7 -1.12526
Isoelectric_Point 4.25807
Number_of_Hydrogen_Bond_Acceptors 40
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1082.87000
X_logP_energy -15.03150
Interaction Information
Affinity KD=7 uM
Affinity_Assay not specified
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Dual-Color Bioluminescent Sensor Proteins for Therapeutic Drug Monitoring of Antitumor Antibodies.
Release_Year 2018
PMID 29443503
DOI 10.1021/acs.analchem.8b00041