PPIRE13617

Target Protein Information
Protein_Name Zinc finger protein DPF3
Protein_Sequence MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA
Organism_Source Homo sapiens
Functional_Classification PHD finger
Cellular_Localization Nucleus
Gene_Names DPF3
UniProt_ID Q92784
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H4-Nac(1-22)
Peptide_Sequence SGRGKGGKGLGKGGAKRHRKVL
Peptide_Length 22
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)CO)C(C)C)C(=O)O
Chemical_Modification N-term=acetyl
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2204.61
Aliphatic_Index 53.18182
Aromaticity 0.00000
Average_Rotatable_Bonds 3.77273
Charge_at_pH_7 8.08741
Isoelectric_Point 12.83145
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1039.13000
X_logP_energy -14.20869
Interaction Information
Affinity KD=7.4 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2KWN
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Release_Year 2010
PMID 20613843
DOI 10.1038/nature09139