PPIRE13629

Target Protein Information
Protein_Name Calsenilin isoform 4
Protein_Sequence MRQLPAGPSSLACSGCKAGRLVTVPFSSRDAEDQGSREGIGWQPPGRSWAHTTEQEGKHQVAKATVHPPGPDALLLNQVDPVQCCPTRL
Organism_Source Mus musculus
Functional_Classification calcium-binding proteins
Cellular_Localization Cytoplasm
Gene_Names Kcnip3
UniProt_ID P0C092
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PS1HL9
Peptide_Sequence FYFATDYLVQPFMDQLAFHQFYI
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fitc
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2905.32
Aliphatic_Index 72.17391
Aromaticity 0.34783
Average_Rotatable_Bonds 3.73913
Charge_at_pH_7 -1.91276
Isoelectric_Point 4.10657
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 1008.20000
X_logP_energy -1.69180
Interaction Information
Affinity KD=2.4 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Pb2+ Binds to Downstream Regulatory Element Antagonist Modulator (DREAM)and Modulates Its Interactions with Binding Partners: A Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.
Release_Year 2018
PMID 30399317
DOI 10.1021/acschemneuro.8b00335