PPIRE13631

Target Protein Information
Protein_Name Regulatory protein cro
Protein_Sequence MEQRITLKDYAMRFGQTKTAKDLGVYQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA
Organism_Source Escherichia phage lambda
Functional_Classification helix-turn-helix
Cellular_Localization Cytoplasm
Gene_Names cro
UniProt_ID P03040
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cro:1
Peptide_Sequence GQTKTAKDLGVYQSAINKAIHAG
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CN)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2371.68
Aliphatic_Index 80.86957
Aromaticity 0.04348
Average_Rotatable_Bonds 3.52174
Charge_at_pH_7 2.08760
Isoelectric_Point 10.11974
Number_of_Hydrogen_Bond_Acceptors 36
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 1057.75000
X_logP_energy -13.23190
Interaction Information
Affinity KD=25 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A synthetic peptide mimic of Lambda-Cro shows sequence-specific binding in vitro and in vivo.
Release_Year 2012
PMID 22480451
DOI 10.1021/cb200523n