PPIRE13641

Target Protein Information
Protein_Name Transcriptional activator VP30
Protein_Sequence MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRSASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLLLIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIRTIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDKGGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTNPGTCSWSDEGTP
Organism_Source Zaire ebolavirus (strain Mayinga-76)
Functional_Classification viral transcription factor
Cellular_Localization Cytoplasm
Gene_Names VP30
UniProt_ID Q05323
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E30pep-wt
Peptide_Sequence QLESLTDRELLLLIARKTCGSVE
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2588.01
Aliphatic_Index 135.65217
Aromaticity 0.00000
Average_Rotatable_Bonds 3.95652
Charge_at_pH_7 -1.05852
Isoelectric_Point 4.58756
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1126.55000
X_logP_energy -10.63996
Interaction Information
Affinity IC50=1 uM
Affinity_Assay co-immunoprecipitation
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide.
Release_Year 2003
PMID 12912982
DOI 10.1074/jbc.M307036200