PPIRE13659

Target Protein Information
Protein_Name Growth/differentiation factor 8
Protein_Sequence MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Organism_Source Mus musculus
Functional_Classification TGF-beta superfamily
Cellular_Localization Extracellular
Gene_Names Mstn
UniProt_ID O08689
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 1
Peptide_Sequence WRQNTRYSRIEAIKIQILSKLRL
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2886.44
Aliphatic_Index 123.04348
Aromaticity 0.08696
Average_Rotatable_Bonds 4.39130
Charge_at_pH_7 4.99831
Isoelectric_Point 12.08412
Number_of_Hydrogen_Bond_Acceptors 38
Number_of_Hydrogen_Bond_Donors 47
Topological_Polar_Surface_Area 1266.44000
X_logP_energy -9.97352
Interaction Information
Affinity IC50=3.56 uM
Affinity_Assay luciferase reporter assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification.
Release_Year 2017
PMID 28740611
DOI 10.1021/acsmedchemlett.7b00168