PPIRE13661

Target Protein Information
Protein_Name Growth/differentiation factor 8
Protein_Sequence MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Organism_Source Mus musculus
Functional_Classification TGF-beta superfamily
Cellular_Localization Extracellular
Gene_Names Mstn
UniProt_ID O08689
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 3d
Peptide_Sequence XRQNTRYSRIEWIKIQIISKIRL
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification X1=2-naphthyloxyacetyl
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification 2-Naphthyloxyacetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2872.41
Aliphatic_Index 118.69565
Aromaticity 0.08696
Average_Rotatable_Bonds 4.39130
Charge_at_pH_7 4.99831
Isoelectric_Point 12.08412
Number_of_Hydrogen_Bond_Acceptors 38
Number_of_Hydrogen_Bond_Donors 47
Topological_Polar_Surface_Area 1266.44000
X_logP_energy -10.36202
Interaction Information
Affinity IC50=0.32 uM
Affinity_Assay luciferase reporter assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification.
Release_Year 2017
PMID 28740611
DOI 10.1021/acsmedchemlett.7b00168