PPIRE13687

Target Protein Information
Protein_Name Voltage-dependent N-type calcium channel subunit alpha-1B
Protein_Sequence LVTEIADTDNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI
Organism_Source Gallus gallus
Functional_Classification voltage-gated calcium channels; N-type
Cellular_Localization Plasma membrane
Gene_Names CACNA1B
UniProt_ID O73706
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name omega-conotoxin GVIA
Peptide_Sequence ECCSDPRCAKGCGSGSSCNPYIDK
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2480.76
Aliphatic_Index 20.41667
Aromaticity 0.04167
Average_Rotatable_Bonds 3.29167
Charge_at_pH_7 -0.31066
Isoelectric_Point 6.12220
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 42
Topological_Polar_Surface_Area 1085.12000
X_logP_energy -17.70133
Interaction Information
Affinity KD=68 pM
Affinity_Assay radioligand binding assay (New Binding Method)
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Characteristics of omega-conotoxin GVI A and MVIIC binding to Cav 2.1 and Cav 2.2 channels captured by anti-Ca2+ channel peptide antibodies.
Release_Year 2005
PMID 16076016
DOI 10.1007/s11064-005-2681-5