PPIRE13690

Target Protein Information
Protein_Name Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Protein_Sequence FVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIEEEDDESAITQHNNFRTFFQALMLLFRSATGEAWHEIMLSCLSGKPCDENSGIKEDECGNEFAYFYFVSFIFLCSFLMLNLFVAVI
Organism_Source Gallus gallus
Functional_Classification voltage-gated calcium channels; P/Q-type
Cellular_Localization Plasma membrane
Gene_Names CACNA1A
UniProt_ID O73705
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name omega-conotoxin MVIIC
Peptide_Sequence GCCPDRHTCGGYEHGAIPGTSCSN
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2422.62
Aliphatic_Index 20.41667
Aromaticity 0.04167
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.06673
Isoelectric_Point 6.46860
Number_of_Hydrogen_Bond_Acceptors 40
Number_of_Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1053.14000
X_logP_energy -17.39243
Interaction Information
Affinity KD=60 pM
Affinity_Assay radioligand binding assay (New Binding Method)
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Characteristics of omega-conotoxin GVI A and MVIIC binding to Cav 2.1 and Cav 2.2 channels captured by anti-Ca2+ channel peptide antibodies.
Release_Year 2005
PMID 16076016
DOI 10.1007/s11064-005-2681-5